DTN 162: Implantable living materials deliver drugs on demand
Plus: Helium-3 lunar gold rush, Virgin Galactic to begin commercial service, Cowboy files for 20k orbital data centers, non-viral gene therapy, real life gundams, and more.

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"If we're going to be making more cars, more robots, more clothes, more food, we're going to need more water. And if we're doing that, we're going to generate more wastewater. If we don't solve this problem, there's going to be a bottleneck."

Implantable 'living materials' that deliver drugs on demand could help fight infections
"To treat an infection, doctors have to find and diagnose it first. But a new approach involving what researchers are calling "living materials" could fundamentally change that. Designed to sit inside your body and activate when needed to help fight infections at the source, the strategy could dispense with the need for pills, shots and even diagnostics.
In a new study published in Science on Thursday, researchers describe successfully implanting a mouse with a "living material" made with genetically engineered bacteria to treat an infection. The technology, if validated in humans, could be used to help prevent infection in surgeries or as a long-term therapeutic that automatically responds to pathogens.
"Living" medicine isn't totally new. Scientists already knew that bacteria can be programmed to sense pathogens and self-destruct when they do so, releasing drugs to kill the invader.
But researchers have been wary about such approaches. "One of the big concerns that everyone has is that we're injecting live bacteria into our body," says Tetsuhiro Harimoto, the study's lead author and a postdoctoral fellow at Harvard University. "We don't want them to disseminate and cause infections."
To solve the problem, Harimoto and his colleagues built a "hydrogel," or jellylike, container. It's permeable like a mesh yet stiff enough to contain a live and growing population of bacteria without bursting open and strong enough to withstand some wear and tear."

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- Cowboy files plans for up to 20,000 orbital data centers
- Flagship startup, Serif, says it has solved non-viral gene therapy in monkeys


The Unitree GD01 in its upright bipedal stance — the robot also drops to four limbs for improved stability on rough terrain. Image: Unitree
“Unitree Robotics has launched the GD01, a rider-carrying robot it describes as the world's first mass-produced manned mech suit, starting at RMB 3.9 million — roughly $537,000. That's a significant correction from the $650,000 figure that circulated at launch; ChinaBizInsider confirmed the actual price alongside details of Unitree's concurrent Shanghai IPO filing. For now, it's a China-only story — no US or UK distributor has been announced.
The machine The GD01 weighs around 500kg with a pilot on board and stands more than twice the height of an average person when fully upright. Its headline trick is transformation: the robot shifts between two-legged and four-legged movement, with the frame also tilting from vertical to horizontal for rough terrain. Bipedal mode mimics a walking gait; quad mode adds stability on uneven ground. Think of it less as a humanoid robot and more as a walking vehicle." (via Gagadget)

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- Body-compatible electrode developed: Rigid on insertion, soft once inside
- Memristor chip merges memory and computing, cutting AI power use by more than half
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- Cracking the code of hypersonic flight: A decade of experiments maps turbulent physics of ultra-fast travel

- Anduril raises $5B for autonomous defense systems and weapons platforms
- Isomorphic Labs raises $2.1B Series B for an AI-first drug design and development platform
- Helsing raises $1.2B for AI-powered military drones
- Recursive Superintelligence raises $650M for AI that automates machine learning research and self-modifies neural architectures
- HawkEye 360 raises $416M IPO for satellite-based RF signal analysis
- Mind Robotics raises $400M for AI-powered full-stack robotics platform automating manufacturing
- Cowboy raises $275M Series B for rockets with orbital AI data center upper stages
- Fractile raises $220M Series B for AI inference chips optimized to overcome memory bandwidth limitations
- Photonic raises $200M USD for fault-tolerant quantum computing via optically-linked silicon spin qubits
- Create Medicines raises $122M Series B for mRNA-LNP platform that programs immune cells in vivo
- Creotech raises $118M for small satellite manufacturing and a new satellite factory
- Havoc AI raises $100M Series A for software enabling one operator to control thousands of autonomous drones and vessels
- WIRobotics raises $68M Series B for wearable walking-assist and humanoid robotic systems
- Star Catcher raises $65M for an orbital power grid infrastructure
- GridCARE raises $64M Series A for physics-based AI to unlock underutilized grid capacity
- UroMems raises $60M for an automated electronic artificial urinary sphincter implant
- NVision raises $55M Series B for real-time metabolism measurement on standard MRI systems
- BlueWind Medical raises $47.8M for implantable tibial neuromodulation devices treating urgency urinary incontinence
- eyeo raises €40M Series A for nanophotonic light-splitting camera sensor hardware
- Degron Therapeutics raises $40M Series A extension for molecular glue-based targeted protein degradation medicines
- Mantle8 raises €31M Series A for natural hydrogen exploration and subsurface modeling
- Judgment Labs raises $32M Seed and Series A for improving AI agents from production data
- Heaviside Industries raises $28M Series A for multi-domain autonomous precision munitions
- Iceotope Technologies raises $26M Series B for chassis-based precision liquid cooling for data centers
- Crew Carbon raises $25M Series A for wastewater treatment process intensification that removes greenhouse gases
- Wirestock raises $23M for datasets of images, videos, and 3D content for AI labs
- Butterfly Medical raises $21M Series C for a non-surgical device treating benign prostatic hyperplasia
- Algorithmiq raises €18M for quantum software enabling drug discovery and molecular simulation
- Meatly raises £10.4M Series A for lab-grown cultivated meat for pet food
- ParcelBio raises $13M for a programmable mRNA platform
- Casimir raises $12M Series B for semiconductor chips that generate power from quantum vacuum
- Urologic Health raises $11M seed for a catheter-free, non-invasive bladder urodynamic testing platform
- White Circle raises $11M seed for an AI control and safety platform that tests, protects, and monitors AI models in real time
- Graphon AI raises $8.3M seed for a pre-model intelligence layer mapping multimodal data connections
- Origin Lab raises $8M seed for turning licensed game worlds into structured AI training data
- Infex Therapeutics raises £4.3M for novel anti-infective therapies targeting drug-resistant infections
- Scarlet Therapeutics raises £3.2M for lab-grown engineered red blood cell therapies targeting metabolic diseases
- Avant Genomics raises $3M+ for fully-automated liquid biopsy sample preparation for cancer detection
- NanoStruct raises €2.6M for rapid identification of harmful bacteria in food
- Tolemy Bio raises €1.4M pre-seed for a virtual-cell intelligence layer for biopharma
- Ampa raises undisclosed funding for a portable FDA-cleared TMS device for depression

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